Novel controlled release formulations of tetracycline compounds

Details Novel controlled release formulations of tetracycline compounds Novel controlled release formulations of tetracycline compounds

1987-10-06

1989-06-06

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424468, 424469, 424489, 424490, 424494, 424497, 424499, 424500, 424501, A61K 964, A61K 922, A61K 916, A61K 950

Patent

active

048370304

ABSTRACT:
Pharmaceutical compositions comprising spherical granules including thereon or therein a 7- or 9-akylamino-6-deoxy-6-demethyltetracycline or an acid-addition salt thereof blended with at least one excipient are adapted to control the rate of drug release in the stomach and in the intenstine in order not to produce nausea or dizziness upon oral administration during antibacterial therapy.

REFERENCES:
patent: 3901942 (1975-08-01), Bernardi et al.
patent: 3960757 (1976-06-01), Morishita et al.
patent: 4038315 (1977-07-01), Tobkes
patent: 4154827 (1979-05-01), Cox et al.
patent: 4207258 (1980-06-01), Broggi et al.
patent: 4500458 (1985-02-01), Villax et al.
patent: 4622244 (1986-11-01), Lapka et al.

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