Novel compounds with collagenase-inhibiting activity, a process

Details Novel compounds with collagenase-inhibiting activity, a process Novel compounds with collagenase-inhibiting activity, a process

1988-01-05

1990-04-17

Evans, J. E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

562623, C07C 9310, A61K 3116, A61K 31185, A61K 31165

Patent

active

049181050

ABSTRACT:
The present invention relates to a novel family of chemical compounds possessing a pharmacological activity, in particular a collagenase-inhibiting activity, a process for the production of these compounds and pharmaceutical compositions in which they are present.
According to the invention, these compounds correspond to the general formula: ##STR1## in which: W represents an amino acid residue selected from the group comprising valine, lysine, norleucine and methionine, and

REFERENCES:
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patent: 4504492 (1985-03-01), Wilkinson et al.
patent: 4599361 (1986-07-01), Dickens et al.
patent: 4618708 (1986-10-01), Rogues et al.
patent: 4743587 (1988-05-01), Dickens et al.
Devlin et al, "J. Chem. Soc.", Perkin I, vol. 9, (1975), p. 830-841.

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