Novel compounds, pharmaceutical compositions, and methods for tr

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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514487, 514586, 514595, 514599, 514603, 514620, 558234, 560 9, 560 29, 564 56, 564 85, 564 86, 564162, 564165, 564 27, 564 49, 564 51, C07D20700, C07C12500, C07C10330, C07C10338

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active

050990306

ABSTRACT:
The present invention relates to beta-aminoethyl-substituted phenyl compounds, especially beta-aminoethoxy-substituted phenyl compounds. The present invention also relates to pharmaceutical compositions comprising a safe and effective amount of a compound of the present invention and a pharmaceutically-acceptable carrier. The present invention further relates to methods for producing analgesia and reducing inflammation, in humans and lower animals, by administering the compounds or compositions of the present invention. In addition, the present invention relates to methods for making compounds of the present invention and intermediates useful in these synthesis methods.

REFERENCES:
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Ferris, A. B., "New Approach to Insecticidal Paints", Aust. Commonwealth Dep. Supply Def. Stand. Lab., Tech. Note No. 89, 3 (1966) (Chem. Abs. 67: 22919a) (abstract only).
Hegyes, P. & S. Foldeak, "Synthesis of Homovanillic Acid Derivatives of Capsaicin-Like Effect", Acta. Phys. Chem., vol. 20 (1974), pp. 115-120.
Michalska, Z., L. Grodzinska & A. Zmuda, "Synthesis and Local Anesthetic Properties of N-Substituted 3,4-Dimethoxyphenethylamine Derivatives", Dept. Pharm. Pharmacol., vol. 24 (1972), pp. 17-25 (Chem. Abs. 77: 19271a) (abstract only).
Nelson, E. K., "Vanillyl-Acyl Amides", J. Am. Chem. Soc., vol. XLI (1919), pp. 2121-2130.

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