Novel compounds: N-disubstituted amino-ethyl esters of raubasine

Details Novel compounds: N-disubstituted amino-ethyl esters of raubasine Novel compounds: N-disubstituted amino-ethyl esters of raubasine

1975-07-10

1977-01-11

Randolph, John D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

42424855, 424250, 424267, 2602472B, 260268PC, C07D47104

Patent

active

040026337

ABSTRACT:
As novel compounds: N-disubstituted amino-ethyl esters of raubasine of the general formula: ##STR1## in which: R.sub.1 and R.sub.2 are alkyl radicals or form together with the nitrogen atom to which they are attached a heterocyclic ring of the morpholinyl, piperidinyl, piperazinyl or pyrrolidinyl type.
Preparation of the compounds by reacting raubasinic acid with a halide of a substituted amino-ethane of the formula ##STR2## R.sub.1 and R.sub.2 have the same significance and X is a halogen in an organic solvent in the presence of an alkali carbonate insoluble in the reaction medium.

REFERENCES:
patent: 3104243 (1963-09-01), Gillo
patent: 3337561 (1967-08-01), Mueller

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