Novel compounds exhibiting a vasodilating activity and inhibitor

Details Novel compounds exhibiting a vasodilating activity and inhibitor Novel compounds exhibiting a vasodilating activity and inhibitor

1990-08-30

1991-10-22

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 89, 546 90, C07D45504, C07D51316

Patent

active

050596926

ABSTRACT:
Novel compounds represented by the formula: ##STR1## wherein R.sub.1 represents an alkyl group having 1 to 3 carbon atoms, R.sub.2 represents an amino group or a group of formula ##STR2## in which R.sub.4 represents an alkyl group having 1 to 3 carbon atoms, R.sub.5 represents an alkyl group having 1 to 3 carbon atoms or may combine with R.sub.6 to form a five or six membered ring containing 4 to 5 carbon atoms, R.sub.6 represents a hydrogen atom or may combine with R.sub.5 to form a five or six membered ring containing 4 to 5 carbon atoms, R.sub.3 represents a hydrogen atom, an alkyl group having 1 to 3 carbon atoms or a halogen atom, X represents a carbonyl group or a methylene group, Y represents a sulfur atom or a vinylene group and pharmaceutically acceptable salts thereof which exhibit a vasodilating activity and inhibitory activity for platelet aggregation. Thus, they are useful as therapeutic agents for treatment of angina pectoris, hypertension, throbosis and the like.

REFERENCES:
patent: 4064247 (1977-12-01), Farge et al.
Yang et al., "The First Synthesis of . . . ", J. Heter. Chem. 26(3), 865-8 (1989).

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