Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...
Patent
1976-01-12
1978-09-12
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Reduced antigenicity, reduced ability to bind complement, or...
2601125R, A61K 3700, C07C10352
Patent
active
041138589
ABSTRACT:
Synthetic compounds of the formula: ##STR1## are disclosed wherein X is an integer of at least 0 and A and B each represent a divalent moiety of the formula: ##STR2## WHEREIN R.sub.1 and R.sub.5 are each selected from the residue of an amino acid or a polypeptide; R.sub.2 represents the residue of tryptophan or tyrosine; R.sub.3 represents the residue of an amino acid; R.sub.4 represents the residue of lysine; arginine or histidine; a is an integer of 0 to 4, inclusive; b and c are each integers of at least 0; m is an integer of from 0 to 1, inclusive; and n is an integer of at least 1; provided that when R.sub.1 or R.sub.5 is the residue of a polypeptide, the corresponding b or c is 1.
The disclosure is also of intermediate compounds for preparing the compounds of the above formula and derivative compounds having biological activity.
Disclosed also are pharmaceutical compositions wherein the essential active ingredient is a synthetic compound of the invention and methods of using them for the prevention, suppression, treatment and diagnosis of multiple sclerosis.
REFERENCES:
patent: 3247180 (1966-04-01), Schwyzer et al.
patent: 3864481 (1975-02-01), Hashim
patent: 3941162 (1976-03-01), McCabe et al.
E. H. Eylar, et al., J. Biol. Chem., 246, No. 18, (1971), pp. 5770-5784.
Phillips Delbert R.
St. Luke's Hospital
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