Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1984-12-21
1988-06-21
Wiseman, Thomas G.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
435212, 424 9463, 424 9464, 424 942, C12N 968, C12N 948, A61K 3748
Patent
active
047525819
ABSTRACT:
A fibrinolytically active hybrid protein which comprises one chain of a 2-chain protease linked to a chain of a different 2-chain protease, or to the same chain of the same protease, at least one of the chains in the hybrid protein being derived from a fibrinolytically active protease, such that the hybrid protein has a catalytic site essential for fibrinolytic activity which is optionally blocked by a removable blocking group.
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patent: 4545988 (1985-10-01), Nakayama et al.
patent: 4600580 (1986-07-01), Smith
Summaria, L. et al., J. Biol. Chem, vol. 254, pp. 6811-6814, 1979.
Robbins, K. C. et al., Biochemistry, vol. 25, pp. 3603-3611, Jun. 1986.
Jackson et al, Biochem. 1982, 21, 6620-6625.
Summaria et al, J. Biol. Chem. 251, No. 18, 5810-5813 (1976).
Dodd Ian
Robinson Jeffery H.
Beecham Group p.l.c.
Huleatt Jayme A.
Wiseman Thomas G.
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