Novel compositions and process for inhibiting digestion in blood

Details Novel compositions and process for inhibiting digestion in blood Novel compositions and process for inhibiting digestion in blood

1989-04-07

1991-04-30

Moskowitz, Margaret

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

8 to 10 amino acid residues in defined sequence

A61K 3738, C07K 1300

Patent

active

050119095

ABSTRACT:
The subject invention concerns three novel peptides which have the property of interfering with the biosynthesis of the enzyme trypsin in an insect gut. This property enables the use of these peptides to inhibit the formation of progeny in blood-ingesting insects, since trypsin is an essential enzyme for food digestion which provides the essential building blocks for egg development in such insects.

REFERENCES:
patent: 4395404 (1983-07-01), Low et al.
Borovsky, D. (1985) "Isolation and Characterization of Highly Purified Mosquito Oostatic Hormone", Arch. Insect Biochem. Physiol. 2:333-349.
Borovsky, D. (1988) "Oostatic Hormone Inhibits Biosynthesis of Midgut Proteolytic Enzymes and Egg Development in Mosquitoes", Arch. Insect Biochem. Physiol. 7:187-210.

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