Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1989-08-28
1991-09-10
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
264 46, 436829, A61K 3722, B01J 1302
Patent
active
050472453
ABSTRACT:
The present invention describes a composition consisting of liposomes covalently or non-covalently coupled to the glycoprotein streptavidin. The streptavidin may additionally be coupled to biotinated proteins such as Immunoglobulin G or monoclonal antibodies. The liposomes of the invention may have a transmembrane potential across their membranes, and may be dehydrated. In addition, the composition may contain ionizable bioactive agents such as antineoplastic agents, and may be used in diagnostic assays.
REFERENCES:
Uptake of Antineoplastic Agents into Large Unilamellar Vesicles in Response to a Membrane Potential, Mayer et al, BBA 816, 294 (1985), Jun. 27, 85 issue.
Bally Marcel B.
Gullis Pieter R.
Loughrey Helen
Bloom Allen
Kishore G. S.
Kurtz Catherine L.
Page Thurman K.
The Liposome Company Inc.
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