Novel clavam derivatives and methods of making same

Details Novel clavam derivatives and methods of making same Novel clavam derivatives and methods of making same

1986-08-27

1989-01-03

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

435119, 540362, C07D49804, C07D20508, C12P 1718, C12P 1465

Patent

active

047958090

ABSTRACT:
A compound having the formula (I): ##STR1## is described, together with salts thereof and an enzymatic process for converting such compounds into clavulanic acid.
A process for the preparation of the compound of formula (I) and its salts is disclosed, together with intermediates for use therein. This process involves the use of a novel enzyme system to effect the desired cyclization, which enzyme system is preferably derived from a micro-organism, in particular a species of Streptomyces.

REFERENCES:
patent: 4078067 (1978-03-01), Christenser
Ivanitskaya, Chem. Abs. 103, 213286e.
Muller, J. Antibiotics 36, 217.
"Protecting Groups", Green et al., Chapters 5 and 7.
"Biochemistry", 2nd edition, Lehniger, pp. 886-887 and 118-119.

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