Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1982-05-07
1984-02-07
Reamer, James H.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
424308, 424312, 424320, 560251, 560110, 564159, 2604045, C07C12912, A61K 3702
Patent
active
044303467
ABSTRACT:
The novel compound represented by the general formula (I) ##STR1## (wherein R represents a hydrogen atom, an alkanoyl group of 1 to 14 carbon atoms, or an arylcarbonyl group), and an acid addition salt thereof [on condition that when R is a hydrogen atom, the hydrochloride exhibits an optical rotation of [.alpha]sub.D.sup.22 -1.degree. .+-.2.degree. (c, 2 water)] has antitumor activity in experimental animals.
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patent: 3436463 (1969-04-01), Mayhew et al.
patent: 4041077 (1977-08-01), Ghosez et al.
patent: 4334097 (1982-06-01), Schmidt
Shoji et al., J. Antibiotics, vol. 29, #4, pp. 390-393 (1976).
Umezawa et al., "Journal of Antibiotics", vol. 34, No. 12, pp. 1622-1624, 1981.
Kondo et al., "Journal of Antibiotics", vol. 34, No. 12, pp. 1625-1627, 1981.
Fujii Akio
Iinuma Hironobu
Ikeda Daishiro
Kondo Shin-ichi
Nakamura Teruya
Bristol-Myers Company
Carnahan Robert E.
Reamer James H.
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