Novel calcitonin derivative and salt thereof

Details Novel calcitonin derivative and salt thereof Novel calcitonin derivative and salt thereof

1989-05-17

1991-04-23

Lee, Lester L.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Calcitonin; related peptides

530324, C07K 736

Patent

active

050101749

ABSTRACT:
There is disclosed a calcitonin derivative and its salt, comprising an amino acid residue at the 1-position of calcitonin which is a cyclic amino acid residue represented by the formula: ##STR1## wherein X represents a sulfur atom or a methylene group; and n represents an integer of 0 or 1. and an amino acid residue at the 7-position which is a cysteine residue which may be substituted with an appropriate protective group.

REFERENCES:
patent: 4212795 (1980-07-01), Hughes et al.
patent: 4622386 (1986-11-01), Orlowski et al.
patent: 4820804 (1989-04-01), Orlowski et al.
patent: 4845080 (1989-07-01), Fisher et al.

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