Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...
Patent
1981-02-17
1983-03-29
Fan, Jane T.
Drug, bio-affecting and body treating compositions
Conjugate or complex of monoclonal or polyclonal antibody,...
Conjugated via claimed linking group, bond, chelating agent,...
536 71, 549264, 424279, 435 76, 435119, A61K 3171, C07D49320
Patent
active
043783538
ABSTRACT:
There are disclosed certain new compounds related to C-076 compounds which have been produced by a mutant of the culture that produced the original C-076 compounds and isolated from the fermentation broth thereof. The compounds retain the C-076 16-membered cyclic backbone, however, the groups attached thereto are considerably modified from the original C-076 compounds. The new compounds have been found to retain the biological activity of the parent C-076 compounds. The compounds are thus potent antiparasitic agents and compositions and methods for such uses are also disclosed.
REFERENCES:
patent: 3950360 (1976-04-01), Aoki et al.
patent: 3984564 (1976-10-01), Aoki et al.
patent: 4134973 (1979-01-01), Fisher et al.
patent: 4285963 (1981-08-01), Arison et al.
Tetrahedron Letters 10, pp. 711-714 (1975).
Goegelman Robert T.
Gullo Vincent P.
Kaplan Louis
Fan Jane T.
Merck & Co. , Inc.
Monaco Mario A.
Rose David L.
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