Novel bisphenoxy carboxylic acid derivatives and their salts

Details Novel bisphenoxy carboxylic acid derivatives and their salts Novel bisphenoxy carboxylic acid derivatives and their salts

1974-07-23

1977-02-15

Killos, Paul J.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260246B, 2602472B, 260268C, 2602938, 260295M, 260303R, 260307R, 26032647, 260345, 2603473, 260471C, 260471A, 260559, 424328, C07C 6966

Patent

active

040082652

ABSTRACT:
Bisphenoxy carboxylic acid derivatives useful as an antiarteriosclerosis agent with good absorbability and low toxicity, which are novel compounds represented by the general formula, ##STR1## wherein R.sub.1 and R.sub.2 represent hydrogen atoms or lower alkyl groups and A represents ##STR2## (wherein in case R.sub.3 is a hydrogen atom, R.sub.4 represents an amino-lower-alkyl group, an N-lower-alkylaminoalkyl group, a heterocyclic group, or a heterocyclic group-substituted alkyl group; or R.sub.3 and R.sub.4 may join through an intermediary hetero atom to form a heterocyclic group and if said hetero atom is a nitrogen atom, this nitrogen atom can bear a lower alkyl group as a substituent) or ##STR3## (wherein R.sub.5 represents a hydrogen atom, a hydroxyalkyl group or a derivative thereof, and R.sub.6 represents a hydroxyalkyl group or a heterocyclic group; or R.sub.5 and R.sub.6 may join to form a cyclic group, or may join through another intermediary hetero atom to form a heterocyclic group and if said hetero atom is a nitrogen atom, this nitrogen atom can bear a lower alkyl group as a substituent), are prepared by reacting a bisphenoxy acid represented by the general formula, ##STR4## wherein R.sub.1 and R.sub.2 have the same meanings as defined above, or a reactive derivative thereof with a hetero atom-containing alcohol compound represented by the general formula, ##STR5## wherein R.sub.3 and R.sub.4 have the same meanings as defined above, an amine derivative represented by the general formula, ##STR6## wherein R.sub.5 and R.sub.6 have the same meanings as defined above, or a salt thereof. Alternatively, the bisphenoxy carboxylic acid derivatives represented by the said general formula (I), wherein A is ##STR7## R.sub.5 is hydrogen and R.sub.6 is a hydroxyalkyl group, are prepared by heating a bisphenoxy acid derivative represented by the general formula, ##STR8## wherein R.sub.1 and R.sub.2 have the same meanings as defined above and X represents an alkylene chain.

REFERENCES:
patent: 3474128 (1969-10-01), Griot
patent: 3542795 (1970-11-01), Griot
patent: 3668234 (1972-06-01), Griot
patent: 3716583 (1973-02-01), Nakamura et al.
patent: 3970694 (1976-07-01), Minai et al.

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