Novel bicycloheptene derivatives

Details Novel bicycloheptene derivatives Novel bicycloheptene derivatives

1976-06-17

1978-02-14

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

2603453, 260464, 260465F, 260165R, 260514D, 260557B, 260559R, 260586F, 260598, 260549, 260617R, 424317, 424320, 424324, 560121, 560256, 542426, C07C17700, C07C 6138, C07C 6974

Patent

active

040739333

ABSTRACT:
Novel bicycloheptene compounds of the formula: ##STR1## wherein A is C.sub.2 -C.sub.4 alkylene; X and B are each ethylene or vinylene; R.sub.1 is hydrogen, C.sub.1 -C.sub.8 alkyl, C.sub.4 -C.sub.8 alkoxyalkyl, C.sub.5 -C.sub.7 cycloalkyl, C.sub.5 -C.sub.8 cycloalkylalkyl, aryl, C.sub.7 -C.sub.10 arylalkyl, C.sub.7 -C.sub.10 aryloxyalkyl; R.sub.2 is hydrogen, or C.sub.1 -C.sub.4 alkyl; and Z is carboxyl, C.sub.2 -C.sub.5 alkoxycarbonyl or C.sub.1 -C.sub.5 carbamoyl, and its non-toxic salts, which are useful as antiulcers, gastric secretion inhibitors, central nervous system regulators, and labor inducing agents.

REFERENCES:
patent: 3933842 (1976-01-01), Chadha et al.
patent: 3959263 (1976-05-01), Abraham et al.
Leeney et al., Prostaglandins, II, 953, (1976).
Corey et al., Tet. Letters, 737, 1976.

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