Novel beta-lactams containing amino acid substituents

Details Novel beta-lactams containing amino acid substituents Novel beta-lactams containing amino acid substituents

1988-09-22

1989-11-28

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D20508, C07D41714, C07D41712, A61K 31425

Patent

active

048838691

ABSTRACT:
An antimicrobially active compound of the formula ##STR1## and pharmaceutically acceptable salts thereof: wherein R.sub.1 is hydrogen, --OCH.sub.3, or --NH--CHO; R.sub.2 is an acyl group derived from a carboxylic acid; R.sub.3 is selected from the group consisting of --CH.sub.2 --, --CH.sub.2 CH.sub.2 --, --CH.sub.2 CH.sub.2 CH.sub.2 --, and --CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 -- and when X is NL.sub.2 L.sub.3 then --CH.sub.2 CH.sub.2 --, --CH.sub.2 CH.sub.2 CH.sub.2 --, and --CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 -- are optionally substituted with one substituent selected from the group consisting of (C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4)carboxyalkyl, or (C.sub.1 -C.sub.4)alkylthio; X is --NL.sub.2 L.sub.3 or a pyrrole of the formula ##STR2## wherein L.sub.1 is hydrogen, --CO--O--CH.sub.2 --(C.sub.6 H.sub.5), or SO.sub.3 H; L.sub.2 is hydrogen, or SO.sub.3 H; and L.sub.3 is hydrogen, --CO--(C.sub.1 -C.sub.4)alkyl; --CH.dbd.NH, --C(NH.sub.2)=NH, --CO--O--CH.sub.2 --(C.sub.6 H.sub.5), --COH, or --SO.sub.3 H with the proviso that if one of L.sub.2 or L.sub.3 is --SO.sub.3 then the other is hydrogen.

REFERENCES:
patent: 4478749 (1984-10-01), Koster et al.
Chambers et al., Chem. Abs. 106, 18244 (7-16-86).

Affiliated with

Also associated with

Rating

Novel beta-lactams containing amino acid substituents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Novel beta-lactams containing amino acid substituents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel beta-lactams containing amino acid substituents will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-582947