Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1978-05-18
1980-08-19
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
2605706, A61K 31135, C07C 9116, C07C 9122, C07C 9134
Patent
active
042184797
ABSTRACT:
Racemic or optically active .alpha.-(2,3,4-trimethoxyphenethylaminomethyl)-2-hydroxybenzylalcohol [I] may be prepared by condensing 2,3,4-trimethoxyphenethylamine with 2-benzyloxyphenylglyoxal or its hydrate, reducing the resultant .alpha.(2,3,4-tri-methoxyphenethylimino)-2-benzyloxyacetophenone to give .alpha.(2,3,4-trimethoxyphenethylaminomethyl)-2-benzyloxybenzylalcohol, if required, resolving the 2-benzyloxybenzylalcohol derivative into each of its optically active enantiomers, and subjecting the racemic modification or optically active enantiomer of said 2-benzyloxybenzylalcohol derivative to catalytic hydrogenation. The compound [I] and pharmaceutically acceptable acid addition salts thereof are useful as anti-diabetic agents. They may be also used in the treatment of thrombosis.
REFERENCES:
patent: 3869474 (1975-03-01), Miura et al.
patent: 3952021 (1976-04-01), Ikezaki et al.
patent: 4032575 (1977-06-01), Ikezaki et al.
patent: 4072759 (1978-02-01), Ikezaki et al.
patent: 4131686 (1978-12-01), Ikezaki et al.
Ikezaki Muneyoshi
Inamasu Masanori
Iwai Hajime
Morita Takashi
Otsuka Hisao
Robinson Douglas W.
Tanabe Seiyaku Co. Ltd.
LandOfFree
Novel benzylalcohols and pharmaceutical compositions and use the does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Novel benzylalcohols and pharmaceutical compositions and use the, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel benzylalcohols and pharmaceutical compositions and use the will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1427951