Novel benzothienyl amino (propyl and butyl) ketones, a method of

Details Novel benzothienyl amino (propyl and butyl) ketones, a method of Novel benzothienyl amino (propyl and butyl) ketones, a method of

1976-03-31

1980-01-29

Siegel, A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

2603265SA, 544 69, 544131, 546202, 424275, 42424851, 424267, 424274, 546194, 546274, 546 13, 2603303, 2602444, C07O33352, C07O20712, A01N 900, A01N 922

Patent

active

041861361

ABSTRACT:
Compounds having the formula ##STR1## wherein R.sub.1 and R.sub.2 are alkyl having one to 4 carbon atoms, allyl or ##STR2## is pyrrolidino, piperidino, perhydroazepino or morpholino, RX is an inorganic acid, organic acid or an alkyl bromide or iodide, m is 3 or 4, and n is zero or one. The compounds are prepared by (1) reacting benzothienyl-lithium with ##STR3## followed by hydrolysis, or (2) when the substituent is located at the 2 position of the benzothienyl group, by reacting benzothiophene with ##STR4## followed by reaction with ##STR5## The compounds possess blood-plaque aggregation, spasmolytic, analgesic, anti-inflammatory and coronary, cerebral and peripheral vaso-dilatory properties.

REFERENCES:
patent: 3417087 (1968-12-01), Campaigne et al.

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