Novel benzothienyl amino (propyl and butyl) ketones

Details Novel benzothienyl amino (propyl and butyl) ketones Novel benzothienyl amino (propyl and butyl) ketones

1979-09-19

1981-02-03

Randolph, John D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546274, C07D33358

Patent

active

042490146

ABSTRACT:
Compounds having the formula ##STR1## wherein R.sub.1 and R.sub.2 are alkyl having one to 4 carbon atoms, allyl or ##STR2## is pyrrolidino, piperidino, perhydroazepino or morpholino, RX is an inorganic acid, organic acid or an alkyl bromide or iodide, m is 3 or 4, and n is zero or one. The compounds are prepared by (1) reacting benzothienyl-lithium with ##STR3## followed by hydrolysis, or (2) when the substituent is located at the 2 position of the benzothienyl group, by reacting benzothiophene with ##STR4## followed by reaction with ##STR5## The compounds possess bloodplaque aggregation, spasmolytic, analgesic, anti-inflammatory and coronary, cerebral and peripheral vaso-dilatory properties.

REFERENCES:
Campaigne et al., Chem. Abstracts, vol. 62, cols. 6829 (1965) (abst. of J. Med. Chem. 8, pp. 136-137 (1965).
Campaigne et al., Chem. Abstracts, vol. 71, abst. 3263q (1969) (abst. of U.S. Pat. 3,417,087).
Robba et al., Chem. Abstracts, vol. 86, abstracts 192540a and 192541b (1976).

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