Novel bendroflumethiazide formulations and method

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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424362, A61K 3154, A61K 4700

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active

043047734

ABSTRACT:
New bendroflumethiazide formulations in solid form are provided which are characterized by excellent disintegration and dissolution capabilities even after long periods of storage. The new bendroflumethiazide formulations, for example, in the form of tablets, contain in addition to bendroflumethiazide, a combination of microcrystalline cellulose which serves as a diluent and aids in disintegration of the tablets, lactose which serves as a diluent, optionally starch (in the gelatinized form) which serves as a disintegrant, and one or more auxilliary disintegrants, such as sodium carboxymethyl starch, a tablet lubricant, such as magnesium stearate, and a colorant, if desired.
A method for preparing the above formulations is also provided.

REFERENCES:
patent: 3265573 (1966-08-01), Goldberg
Merck Index, 9th Ed., 1976, entry no. 1042.
Lachman et al., "The Theory & Practice of Industrial Pharmacy", 2nd Ed. (1976), pp. 325-333.

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