Novel bacterial markers for pathogenic group B streptococci

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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435 732, 435 79, 435 35, 435 36, 435 39, 435810, 435820, 435885, 435 72, 436501, 436518, 436804, 436808, 530415, 530825, 5303895, G01N 33569, G01N 3353, C12Q 114

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050988271

ABSTRACT:
The subject invention concerns a novel in vitro process for identifying and quantifying native antigens on potentially pathogenic group B streptococci bacteria present in a clinical specimen. The invention process is made possible by the discovery of novel bacterial markers denoted .gamma. and .delta. epitopes which are expressed by a variety of group B streptococcal strains.

REFERENCES:
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Jelinkova, J. (1977) "Group B Streptococci in the Human Population," Current Topics in Microbiology and Immunology 76:127-165.
Lim, D. V., W. J. Morales, A. F. Walsh and D. Kazanis (1986) "Reduction of Morbidity and Mortality Rates for Neonatal Group B Streptoccal Disease through Early Diagnosis and Chemoprophylaxis," J. Clin. Micro. 23:489-492.
Boyer, K. M. and S. P. Gotoff (1986) "Prevention of Early-Onset Neonatal Group B Streptococcal Disease with Selective Intrapartum Chemoprophylaxis," New England J. Med. 314:1665-1669.
Russell-Jones, G. J., E. C. Gotschlinch, and M. S. Blake (1984) "A Surface Receptor Specific for Human IgA on Group B Streptococci Possessing the Ibc Protein Antigen," J. Exp. Med. 160:1467-1475.
Russell-Jones, G. J. and E. C. Gotschlich (1984) "Identification of Protein Antigens of Group B Streptococci, with Special Reference to the Ibc Antigens," J. Exp. Med. 160:1476-1484.

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