Novel assay system for measuring human plasminogen actuator acti

Details Novel assay system for measuring human plasminogen actuator acti Novel assay system for measuring human plasminogen actuator acti

1989-11-07

1992-03-17

Kepplinger, Esther L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving blood clotting factor

435 74, 435 76, 435 771, 435 23, 435 24, 435184, 435212, 435217, 436 69, 424 9464, C12Q 156, C12Q 138, G01N 3386

Patent

active

050968114

ABSTRACT:
Disclosed is a means useful for selectively inhibiting human tissue plasminogen activator utilizing a thrombin inhibitor, illustrated by D-Phe-Pro-Arg-chloromethyl ketone (PPACK), thus providing a novel assay system for measuring human tissue plasminogen activator activity.

REFERENCES:
patent: 4029694 (1986-12-01), Harpel
patent: 4318904 (1982-09-01), Shaw et al.
patent: 4563420 (1986-01-01), Verheijen et al.
Chemical Abstract 100 (15) 116863, "Quantitation of Tissue-Type Plasminigen Activator . . . by Use of an Enzyme Immunoassay", Rijken et al., Thromb. Res., 33(2), 145-53, 1984.
Chemical Abstract 102(1)2611, "Quantitative Determination of Tissue-Type Plasminogen Activator", Kyowa Co., Ltd., Jpn. KOKAI TOKKYO KOHO, JP 59174759 A2, Oct. 3, 1984.
Lijnen et al., "Inhibition of Trypsin-Like Serine Proteinases by Tripeptide Arginyl and Lysyl Chloromethylketones", Thrombosis Research 34; 431-437 (1984).
Kettner, Charles and Shaw, Elliott, Brief Communication, "D-PHE-PRO-ARGCH.sub.2 Cl-A Selective Affinity Label for Thrombin", Thrombosis Research 14; 969-973 (1979).
Korninger, C. Stassen, J. M. and Collen, D., "Turnover of Human Extrinsic (Tissue-Type) Plasminogen Activator in Rabbits", Thromb. Haemostas, (Stuttgart) 46(3) 658-661 (1981).

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