Novel antitumor antibiotic awamycin and its production

Details Novel antitumor antibiotic awamycin and its production Novel antitumor antibiotic awamycin and its production

1983-10-25

1986-09-16

Warren, Charles F.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing nitrogen-containing organic compound

424120, 435886, 536 168, C12P 1300, C12R 1465, A61K 3500, C07G 1100

Patent

active

046122850

ABSTRACT:
A novel antibiotic, awamycin, and its production. Awamycin is active against gram positive bacteria and exhibits growth inhibitory activity against Erhlich ascites and Sarcoma 180 cells. Some of the identifying characteristics of awamycin include a molecular weight of 744.+-.1 (mass spectrum analysis), an elementary analysis of 59.16% C, 6.48% H and 1.88% N; a melting point of 158.degree. C.; an optical rotation of [.alpha]sub.D 24=+836.degree.. Awamycin is an acidic substance, which provides an orange colored powder, and is poorly soluble in water.

REFERENCES:
patent: 3997663 (1976-12-01), Pinnert et al.
patent: 4207313 (1980-06-01), Umezawa et al.

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