Novel antibiotic NCS-C and preparation method of the same

Details Novel antibiotic NCS-C and preparation method of the same Novel antibiotic NCS-C and preparation method of the same

1980-07-28

1982-05-04

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

435169, A61K 3500

Patent

active

043282121

ABSTRACT:
The specification describes novel antibiotic NCS-C and its free acid salts. Their antimicrobial effects are at least comparative with neocarzinostatin, and, against some microorganisms, superior. The novel antibiotic NCS-C or its free acid salt is prepared either by culturing an NCS-C yielding microorganism belonging to the Streptomyces family in a culture medium, separating the culture medium into bacterial bodies and culture filtrate, and extracting the culture filtrate with a water-immiscible polar organic solvent under acidic conditions, or by decomposing neocarzinostatin under acidic conditions and extracting resultant free acid salt with a polar organic solvent.

REFERENCES:
Napier et al., Biochemical and Biophysical Research Communications, 89 (2) pp. 635-642 (1979).

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