Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ketone doai
Patent
1986-06-27
1987-11-24
Reamer, James H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ketone doai
560142, 560130, 558415, 558416, 558427, 558436, 558441, 568775, 568784, 568308, 568337, 568662, 568663, 568627, 564342, 564366, 564372, 564374, 564285, 564223, 564169, 2604105, 562463, 514545, 514546, 514733, 514678, 514649, 514643, 514629, 514621, 514570, A61K 3112
Patent
active
047089660
ABSTRACT:
The present invention relates to novel specifically-substituted phenyl compounds, especially substituted di-tert-butyl phenol derivatives, which are effective as anti-inflammatory, analgesic and/or antipyretic agents. These phenyl compounds are substituted with a low molecular weight alkyl chain which terminates in a specific unsaturated functional group. These unsaturated functionalities are --C.tbd.CH, C.dbd.CH.sub.2, C.dbd.C.dbd.CH.sub.2, and aldehydes in the form of their acetals.
The present invention further relates to pharmaceutical compositions which contain an anti-inflammatory agent of the present invention and a pharmaceutically-acceptable carrier.
Finally, the present invention relates to methods for treating diseases characterized by inflammation, such as rheumatoid arthritis and osteoarthritis, in humans or lower animals. Such methods comprise administering to a human or lower animal in need of such treatment a safe and effective amount of an anti-inflammatory agent or composition of the present invention.
REFERENCES:
patent: Re27004 (1970-12-01), Meier et al.
patent: 3226443 (1965-02-01), Meier et al.
patent: 3335164 (1967-08-01), Scherer et al.
patent: 3477991 (1969-11-01), Patton et al.
patent: 3526668 (1970-09-01), Starnes et al.
patent: 3660505 (1972-05-01), Starnes et al.
patent: 3714122 (1973-01-01), Kline
patent: 4130666 (1978-12-01), Moore
patent: 4172151 (1979-10-01), Moore
patent: 4440784 (1984-04-01), Katsumi et al.
Hauff et al., Chem. Ber., 105 (4), pp. 1446-1455 (1972); and CAS Abstract No. 76: 153273k.
Gavrilov et al., Khim.-Farm. Zh., 12 (9), pp. 42-45 (1978).
Swingle et al., in "Anti-Inflammatory and Anti-Rheumatic Drugs, vol. III" (K. D. Rainsford, Editor; CRC Press, Inc.; 1985), pp. 105-126.
Loomans Maurice E.
Matthews Randall S.
Miller Joseph A.
Allen George W.
Reamer James H.
Schaeffer Jack D.
The Procter & Gamble & Company
Zerby Kim W.
LandOfFree
Novel anti-inflammatory agents, pharmaceutical compositions and does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Novel anti-inflammatory agents, pharmaceutical compositions and , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel anti-inflammatory agents, pharmaceutical compositions and will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2423805