Novel anti-inflammatory agents, pharmaceutical compositions and

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters

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560254, C07C 6976

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active

049122487

ABSTRACT:
Compounds and diastereomeric mixtures of specific 2-naphthyl-containing ester compounds, especially naproxen ester and naproxol ester compounds, having two or more chiral centers. These compounds are effective as anti-inflammatory agents, analgesic agents, and/or antipyretic agents. They are readily absorbed as the diastereomeric mixture, especially through the skin following topical application.

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patent: 4665224 (1987-05-01), Mora
Harrison, I., et al., "Nonsteroidal Anti-Inflammatory Agents, I., 6-Substituted 2-Naphthylacetic Acids", Journal of Medicinal Chemistry, vol. 13 (1970), pp. 203-205.

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