Novel antagonists of the antidiuretic action of arginine vasopre

Details Novel antagonists of the antidiuretic action of arginine vasopre Novel antagonists of the antidiuretic action of arginine vasopre

1981-11-16

1983-08-16

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reduced antigenicity, reduced ability to bind complement, or...

2601125R, A61K 3700, C07C10352

Patent

active

043991254

ABSTRACT:
Compounds acting as antagonists of the antidiuretic activity of arginine vasopressin are those of the formula ##STR1## wherein X is D-Phe, D-Val, D-Leu, D-Ile, D-Arg, D-norvaline, D-norleucine, D-cyclohexylalanine, D-.alpha.-aminobutyric acid, D-threonine or D-methionine and Z is D- or L-Arg.

REFERENCES:
patent: 3371080 (1968-02-01), Boissonnes et al.
patent: 3415805 (1968-12-01), Siedel et al.
patent: 3418307 (1968-12-01), Boissonnes et al.
patent: 3454549 (1969-07-01), Boissonnes et al.
patent: 3497491 (1970-02-01), Zavral et al.
patent: 4148787 (1979-04-01), Mulder et al.
J. Med. Chem. 1981, 24, 701-706; 1980, 23, 364-368; 1978, 21, 313-315; 1975, 18, 1022-1024; 1978, 21, 850-853; 1974, 17, 250-252.
J. Pharm. & Exper. Therap. 174, 1970, 541-549; 1975, 196, 746-757.
Science 161, 1968, 280-281; 212, 1981, 49-51.

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