Novel and improved antibodies for site specific attachment of co

Details Novel and improved antibodies for site specific attachment of co Novel and improved antibodies for site specific attachment of co

1991-02-04

1991-09-10

Doll, John

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 9, 424 858, 424 8591, 530387, 530388, 530390, 530391, 530395, A61K 4902, A61K 3944

Patent

active

050472275

ABSTRACT:
Novel and improved antibody compositions comprising an antibody or antibody fragment having an increased number of sites on a carbohydrate side chain available for the site specific attachment of a compound to a region of the antibody or antibody fragment which is not part of nor directly involved with the antigen binding site are disclosed. Conjugates, prepared using the high-mannose-containing antibodies, which are characterized by substantially the same immunospecificity as the unmodified unconjugated antibody molecule, are also disclosed. The antibody compositions are advantageously used for a wide variety of therapeutic and diagnostic applications in both in vivo and in vitro targeted delivery systems and assays. Methods for preparing the antibody compositions, as well as antibody conjugate intermediates, and methods for using the antibody compositions are also described.

REFERENCES:
patent: 3447893 (1974-10-01), Reading
patent: 4217338 (1980-08-01), Quash
patent: 4419444 (1987-12-01), Quash
patent: 4634666 (1987-01-01), Engleman et al.
patent: 4671958 (1987-06-01), Rodwell et al.
patent: 4699784 (1987-10-01), Shih et al.
patent: 4925796 (1990-05-01), Bergh et al.
O'Shannessy et al., Immunology Letters, 8: 273-177 (1984).
Rodwell et al., Proc. Natl. Acad. Sci. U.S.A., 83: 2632-2636 (1986).
Bunton, in Oxidation in Organic Chemistry, vol. I, Widberg, ed., Academic Press, New York, p. 367 (1965).
Cole et al., in Monoclonal Antibodies and Cancer Therapy, Alan R. Liss, Inc., pp. 77-96 (1985).
Fuhrmann et al., Nature, 307: 755.congruent.758 (1984).
Jackson, "Periodic Acid Oxidations" in Organic Reactions, vol. 2, pp. 341-375 (1944).
Jentoft and Dearborn, J. Biol. Chem., 254: 4359-4365 (1979).
Johnson and Laguzza, Cancer Res., 47: 3118-3122 (1987).
Kohler and Milstein, Sci. Amer., 243: 66-74 (1980).
Kozbor et al., Immunol. Today, 4: 72 (1983).
March, in Advanced Organic Chemistry: Reactions, Mechanisms and Structures, McGraw-Hill Co., New York, pp. 824-825 (1978).
Steer et al (1986), Progress in Liver Disease III, chapt. 6, pp. 99-123.
Biochemistry, 3rd ed by L. Stryer, 1988, Freeman and Company, N.Y., pp. 344 and 777.

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