Novel analogs of deamino-vasopressin with a modified disulfide b

Details Novel analogs of deamino-vasopressin with a modified disulfide b Novel analogs of deamino-vasopressin with a modified disulfide b

1974-10-07

1976-09-14

Gotts, Lewis

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424177, C07C10352, A61K 3700

Patent

active

039806316

ABSTRACT:
Stepwise synthesis in solution and cyclization by means of active esters or another method suitable for peptide bond formation were used to prepare analogues of deamino-vasopressin with the disulphide bridge altered to the thioether group. In sequence position 8 of the peptide chain the analogs differed by the nature of basic amino acid. Typical vasopressin-like activities, mainly antidiuretic, were very high in these analogs; of particular importance will be their haemodynamic activity.

REFERENCES:
hase et al., J. Am. Chem. Soc. 94, 3590-3600 (1972).
Jost et al., Coll. Czech. Chem. Comm., 32, 1229-1241 (1967).
Jost et al., Coll. Czech. Chem. Comm., 36, 234-245 (1971).
Prochazka et al., Coll. Czech. Chem. Comm., 37, 289-298 (1972).
Jost et al., Coll. Czech. Chem. Comm., 36, 2795-2808 (1971).

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