Novel analogs of .beta.-endorphin

Details Novel analogs of .beta.-endorphin Novel analogs of .beta.-endorphin

1977-03-11

1978-03-28

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424177, C07C10352, A61K 3700

Patent

active

040814343

ABSTRACT:
Snythetic analogs of .beta.-endorphin having the sequence .beta.-endorphin-(1-5)-(16-31) are disclosed. These compounds are potent opiate agonists and analgesic agents, having activities in excess of the parent compounds. Moreover, the present analogs lack the antigenic determinent site which is believed to reside in residues 6-15 of .beta.-endorphin. Thus the analogs present a substantially reduced risk of inducing an anaphylactic response in a treated individual.

REFERENCES:
patent: 4038222 (1977-07-01), Li
G. Ungar, et al., Opiates and Endogenous Opioids Peptides, 1976, pp. 121-128.
D. H. Coy, et al., Biochem. and Biophys. Res. Commun. 73, 1976, pp. 632-638.

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