Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1980-01-14
1981-04-07
Roberts, Elbert L.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
26039745, 26023955R, 2603974, A61K 3156, C07J 500
Patent
active
042606055
ABSTRACT:
The present invention relates to novel 21-alkylated steroids of the pregnane series having the formula: ##STR1## wherein R.sub.1 =alkyl (1-4 C); R.sub.2 =carboxyacyl (1-18 C); X=H, F or Cl; Y=O, H(OH), H(lower acyloxy), H(F) or H(Cl) with the proviso that Y is not H(F) when X is F; and the dotted line indicates the optional presence of a double bond, to processes for their preparation and to pharmaceutical compositions containing same.
The novel compounds possess strong anti-inflammatory properties, when applied locally and cause little or systemic, thymolytic, adrenolytic and salt-retaining effects.
REFERENCES:
patent: 3045010 (1962-07-01), Figdor et al.
Chemical Abstracts, vol. 66 (1967), Par. 28973(f) relied on. Publication by Ercoli et al.
Cairns James
Logan Robert T.
McGarry George
Roy Robert G.
Woods Gilbert F.
Akzo N.V.
Roberts Elbert L.
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