Novel alkaline protease M.sub.3 method for the preparation there

Details Novel alkaline protease M.sub.3 method for the preparation there Novel alkaline protease M.sub.3 method for the preparation there

1981-01-15

1982-12-21

Shapiro, Lionel M.

Drug, bio-affecting and body treating compositions

Dentifrices

Ferment containing

435219, 435220, 435886, C12N 950, C12N 952, A61K 728

Patent

active

043649262

ABSTRACT:
Novel alkaline protease M.sub.3 which is distinguished from known alkaline proteases in the phisiochemical properties, particularly in terms of the strong alkaline optimum pH: 9-12.5; being not inhibited by FeSO.sub.4, diisopropyl fluorophosphate, ethylenediamine tetraacetate and iodoacetic acid; having glucosyltransferase inhibitory activity; and having the lowest molecular weight, and which can be produced by cultivating a microorganism of the genus Streptomyces, particularly Streptomyces globisporus B-1829 strain (ATCC 21553). The alkaline protease M.sub.3 is useful for prevention of dental caries.

REFERENCES:
patent: 3713983 (1973-01-01), Yokotsuka et al.
patent: 3751561 (1973-08-01), Wildi et al.
patent: 3838009 (1974-09-01), Fukumoto et al.
patent: 3929579 (1975-12-01), Yoshimura et al.
Abstract of Japanese Patent Application 21786/1971 (Derwent 41838S-BD).
Abstract of Japanese Patent Publication 21786/1971 (Derwent 41839S-BD).
Abstract of Japanese Patent Publication 4501/1972 (Derwent 35385R-B4D16).
Abstract of Japanese Patent Application 9870/1975 (Derwent 52357S-BCD).
Abstract of Japanese Patent Laid Open Application 92582/1973 (Derwent 20290 VII).

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