Novel aldol derivatives and production thereof

Details Novel aldol derivatives and production thereof Novel aldol derivatives and production thereof

1980-02-04

1981-09-29

Jiles, Henry R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

2603405P, 2603407, 2603409P, 568343, 568374, 568443, 568445, C07D31712, C07D31908, C07D33906

Patent

active

042924324

ABSTRACT:
A process for producing novel aldol derivatives of the formula, ##STR1## wherein C=W is a carbonyl group or a protected carbonyl group which comprises reacting a compound of the formula: ##STR2## wherein C=W is as defined above in the presence of an acid or a base at a temperature ranging from -70.degree. C. to room temperature. The novel aldol derivatives of the above formula are useful as intermediate for producing methanoprostacyclin derivatives which are useful medicines for prevention of thrombosis.

REFERENCES:
patent: 3338969 (1967-08-01), Muller et al.
patent: 4191660 (1980-03-01), Schreiber et al.
Wagner et al., Synthetic Organic Chemistry, p. 174 and p. 288.
Nielsen et al., Organic Reactions, vol. 16, p. 47.
Sugie et al., Tetrahedron Letters, pp. 2607-2610, 1979.
Nicolaou et al., J.C.S. Chemical Communications, pp. 1067-1068, (1978).
Shibasaki et al., Tetrahedron Letters, pp. 432-437, 1979.
Kojima et al., Tetrahedron Letters, pp. 3742-3747, 1978.
Morton et al., J. Org. Chem., vol. 44, No. 16, 1979, 2880-2887.
Shibasaki et al., Chemistry Letters, pp. 1299-1300, 1979.
Konishi et al., Chemistry Letters, pp. 1437-1440, 1979.

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