Novel acetylpolyamine amidohydrolase

Details Novel acetylpolyamine amidohydrolase Novel acetylpolyamine amidohydrolase

1988-06-28

1991-01-01

Kepplinger, Esther M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving hydrolase

435228, 435814, 435815, C12Q 134, C12N 980

Patent

active

049817884

ABSTRACT:
A novel acetylpolyamine amidohydrolase is described. The enzyme specifically hydrolyzes the amino bond in acetylputrescine, acetylcadaverine, acetylspermidine and acetylspermine with strong substrate affinity. The enzyme is preferably produced by culturing a microorganism belonging to the genus Mycoplana, and is used in the quantitative determination of polyamine contained in a living body sample, which is useful for cancer diagnosis.

REFERENCES:
Okada et al, Polyamines: Basic and Clinical Aspects, 1985, pp. 72-80.
Chemical Abstracts, vol. 103, 1985, Meito Sangyo Co., Ltd., p. 410, 36189c, "Manufacture of N-Acetylpolyamine amidohydrolase m".

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