Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Patent
1990-05-21
1991-06-25
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
552540, 552548, 552554, 552569, 552589, 552590, 552596, 552598, 552622, 552650, A61K 3156, C07J 900, C07J 700
Patent
active
050266934
ABSTRACT:
Novel esters of 9.alpha.-fluoro- and chloro-corticosteroids of the formula ##STR1## wherein Y is chlorine or OR.sub.1, R.sub.1 and R.sub.2 represent an acyl group of 2-6 carbon atoms or a benzoyl group and where R.sub.1 and R.sub.2 can be the same or different in the same molecule, R.sub.3 is methyl or fluorine in either the .alpha.- or .beta.- orientation, X is chlorine or fluorine, and the C.sub.1 C.sub.2 bond can be saturated or not, especially those compounds of the formula ##STR2## wherein Y and R.sub.2 have the significance given above, are prepared by reacting the respective 9.beta.,11.beta.-epoxy compounds with hydrogen fluoride or chloride.
REFERENCES:
patent: 3312590 (1967-04-01), Elks et al.
patent: 4555507 (1985-11-01), Annen et al.
Heggie William
Page Philip R.
Villax Ivan
Friedman Stanley J.
Gardner Diane
Hovione Inter Ltd.
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