Novel 6-alkyl and 6.8-dialkylbicyclo(4.2.0)octane derivatives

Details Novel 6-alkyl and 6.8-dialkylbicyclo(4.2.0)octane derivatives Novel 6-alkyl and 6.8-dialkylbicyclo(4.2.0)octane derivatives

1988-11-10

1991-01-08

Shippen, Michael L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514569, 514572, 514700, 514703, 514719, 514729, 514824, 560 56, 560116, 560119, 562466, 562498, 562501, 568441, 568445, 568633, 568808, 568819, C07C 6232, A61K 3121

Patent

active

049836277

ABSTRACT:
Compounds useful in treating or preventing gastrointestinal ulcers and in treating cardiovascular disorders such as thrombosis, hypertension and atherosclerosis are depicted in formulas (1), (2) and (3): ##STR1## wherein: A is --C.tbd.C--, trans --HC.dbd.CH--, trans --CH.dbd.CHCH.sub.2 -- or --CH.sub.2 CH.sub.2 --;

REFERENCES:
patent: 4608388 (1986-03-01), Kluge et al.
patent: 4628110 (1986-12-01), Aristoff
patent: 4678805 (1987-07-01), Kluge et al.
patent: 4735966 (1988-04-01), Wu et al.
Journal of Organic Chemistry, vol. 48, 5341-5348 (1983).

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