Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1984-08-20
1988-11-01
Hazel, Blondel
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 29, C07H 1904, C07H 19073
Patent
active
047821426
ABSTRACT:
Compounds for inhibiting the replication of DNA viruses which induce the formation of thymidine kinase enzyme of the formula: ##STR1## wherein R.sub.1 is a radical selected from the group consisting of chloro, iodo, hydroxy, alkoxyalkyl, hydroxyalkyl, methylamino, formyl, nitro, and unsubstituted hydrocarbon groups of 2 to about 3 carbon atoms or halosubstituted hydrocarbon groups of 1 to about 3 carbon atoms; R.sub.2 is hydrogen or hydroxy; and R.sub.3 is hydroxy, --OP(O)(OH).sub.2, amino, or --OCOR.sub.4 where R.sub.4 is alkyl or alkoxyalkyl of 2 to about 18 carbon atoms.
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This invention was made with government support under a Public Health Service Research Grant from the National Cancer Institute: 5-ROI-CA-06695. The government has certain rights to this invention.
Bardos Thomas J.
Cheng Yung-Chi
Efange Simon M. N.
Schroeder Alan C.
Dunn Michael L.
Ellis Howard M.
Hazel Blondel
The Research Foundation of State University of New York
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