Novel 4-alkylthio-steroids

Details Novel 4-alkylthio-steroids Novel 4-alkylthio-steroids

1989-12-21

1991-01-29

Shen, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514178, 514179, 552511, 552515, 552523, A61K 31565, A61K 3156, C07J 100, C07J 3100

Patent

active

049886843

ABSTRACT:
A compound of the formula ##STR1## wherein R is selected from the group consisting of alkyl of 1 to 4 carbon atoms and alkenyl and alkynyl of 2 to 4 carbon atoms, R.sub.1 is alkyl of 1 to 6 carbon atoms unsubstituted or substituted with at least one member of the group consisting of alkoxy and alkylthio of 1 to 4 carbon atoms, --NO.sub.2, --CN and halogen, X and Y together are .dbd.O or Y is hydrogen and X is --OH, etherified --OH or esterified --OH, the dotted lines in the 1(2), 6(7) and 9(11) positions indicate a possible double bond with the proviso that R.sub.1 is alkyl of 1 to 6 carbon atoms when X and Y are .dbd.O and there is a double bond in at least one of the 1(2), 6(7) and 9(11) positions having aromatase inhibiting activity.

REFERENCES:
patent: 4322416 (1982-03-01), Metcalf
patent: 4810423 (1989-03-01), Buzzetti
Faustini et al., "4-Hydroxy Derivatives . . . " CA 109:93430.

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