Novel 4,6-di-O-(aminoglycosyl)-2-deoxystreptamine, method for it

Details Novel 4,6-di-O-(aminoglycosyl)-2-deoxystreptamine, method for it Novel 4,6-di-O-(aminoglycosyl)-2-deoxystreptamine, method for it

1975-05-02

1976-08-31

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 4, 536 17, A61K 3171, C07H 1522

Patent

active

039782140

ABSTRACT:
The novel aminoglycoside, 0-2-amino-2,3,4-trideoxy-.alpha.-D-glycero-hex-4-enopyranosyl-(1.fwdarw.4) -garamine, is prepared by treating Aminoglycoside 66-40C with aqueous acid followed by treatment with a hydride donor reducing agent. Pharmaceutical compositions of the novel aminoglycoside and its pharmaceutically acceptable acid addition salts are described as well as their use as antiprotozoal agents.

REFERENCES:
patent: 3832286 (1974-08-01), Weinstein et al.
patent: 3880828 (1975-04-01), Mallams

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