Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1986-11-20
1989-06-20
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546296, A61K 3144, C07D21186
Patent
active
048409588
ABSTRACT:
Pharmaceutical compositions containing a 3-hydroxyprid-2-one or 3-hydroxypyrid-4-one in which the hydrogen atom attached to the nitrogen atom is replaced by an aliphatic hydrocarbon group of 1 to 6 carbon atoms and, optionally, in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by an aliphatic hydrocarbon group of 1 to 6 carbon atoms, or a salt thereof containing a physiologically acceptable cation, are of value for removing toxic amounts of metals, particularly iron, from the body. These compositions are useful in the treatment of iron overloads.
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"The relationship Between Lipophilicity of Hydroxypyrid-4-One Iron Chelators and Cellular Iron Mobilisation, Using an Hepatocyte Culture Model", by J. B. Porter, M. Gyparaki, E. R. Huehns, R. C. Hider.
"In Vivo Evaluation of Hydroxypyrid-4-One Chelators Intended for the Treatment of Iron Overload by the Oral Route", by M. Gyparaki, J. B. Porter, E. R. Huehns and R. C. Hider.
Hider Robert C.
Kontoghiorghes George
Silver Jack
National Research Development Corporation
Rotman Alan L.
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