Novel 2-substituted 6,7-benzomorphan derivatives and salts there

Details Novel 2-substituted 6,7-benzomorphan derivatives and salts there Novel 2-substituted 6,7-benzomorphan derivatives and salts there

1975-03-17

1976-06-29

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

A61K 31485

Patent

active

039669394

ABSTRACT:
Novel 2-substituted 6,7-benzomorphan derivatives of the formula: ##SPC1##
And acid addition salts thereof, which are useful as non-addicting analgesics, pain relieving agents and antitussives and can be prepared by reacting 6,7-benzomorphan derivatives of the formula: ##SPC2##
With the reactive derivatives of alcohols of the formula: ##EQU1## [wherein R is a hydrogen atom, a hydroxyl group, an alkoxy group or an alkanoyloxy group; R.sub.1 is a hydrogen atom, an alkyl group, an alkoxyalkyl group or a substituted or unsubstituted aryl group; R.sub.3 is a hydrogen atom or a hydroxyl group; R.sub.4 is a hydrogen atom, an alkyl group or a substituted or unsubstituted aryl group, or R.sub.3 and R.sub.4 may form an alkylidene group or a carbonyl group together with the carbon atom to which these substituents are bonded; R.sub.2, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9 and R.sub.10 are each a hydrogen atom or an alkyl group; A is an alkylene group; and m is an integer of 0 to 2].

REFERENCES:
patent: 3632591 (1972-01-01), Albertson et al.
patent: 3776914 (1973-12-01), Atsumi et al.

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