Novel 17-hetero substituted steroids

Details Novel 17-hetero substituted steroids Novel 17-hetero substituted steroids

1988-09-16

1990-05-01

Lipovsky, Joseph A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

540 23, A61K 3158, C07J 7100

Patent

active

049218468

ABSTRACT:
Steroids with a 17-spiro substituent of 3,4 or 6 ring members of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of carbocyclic aryl, heterocyclic aryl and aralkyl, R.sub.2 is a hydrocarbon of 1 to 18 carbon atoms in the .alpha.-or .beta.-position, the wavy line of the spiro ether indicates the oxygen is .alpha.-or .beta.-, X is selected from the group consisting of --CH.dbd.CH--CH.sub.2 --CH.sub.2 -- and --(CH.sub.2).sub.n --, n is 1, 2 or 4, the A and B rings have a structure selected from the group consisting of ##STR2## R' and R" are individually hydrogen or alkyl of 1 to 4 carbon atoms, R.sub.e is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms, substituted alkyl of 1 to 6 carbon atoms and acyl and their non-toxic, pharmaceutically acceptable acid addition salts having a remarkable antiprogestomimetic activity.

REFERENCES:
patent: 3364207 (1968-01-01), Brown
patent: 3422096 (1969-01-01), Brown
patent: 4233296 (1980-11-01), Teutsch et al.
patent: 4536401 (1985-08-01), Neef et al.
patent: 4540686 (1985-09-01), Philibert et al.
patent: 4609651 (1986-09-01), Rohde et al.

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