Novel 17.beta.-hydroxy-19-nor-steroids

Details Novel 17.beta.-hydroxy-19-nor-steroids Novel 17.beta.-hydroxy-19-nor-steroids

1988-12-30

1991-04-09

Sneed, H. M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

552553, 552554, A61K 3156

Patent

active

050065181

ABSTRACT:
Novel 19-nor steroids of the formula ##STR1## wherein R' is selected from the group consisting of propyl, propenyl, iodoethenyl, iodoethynyl or --C.tbd.C--CH.sub.2 --Hal.sub.1, Hal.sub.1 is selected from the group consisting of fluorine, chlorine and bromine and their non-toxic, pharmaceutically acceptable acid addition salts having a remarkable antiglucocorticoid and antiprogestomimetic activity.

REFERENCES:
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patent: 4447424 (1984-05-01), Teutsch et al.
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patent: 4536401 (1985-08-01), Neef et al.
patent: 4547493 (1985-10-01), Teutsch et al.
patent: 4609651 (1986-09-01), Rohde et al.
patent: 4634696 (1987-01-01), Teutsch et al.
patent: 4661295 (1987-04-01), Jouquey et al.
patent: 4774236 (1988-09-01), Cook et al.
patent: 4780461 (1988-10-01), Neef et al.
patent: 4814327 (1989-03-01), Ottow et al.
patent: 4829060 (1989-05-01), Ottow et al.
Structure of 11.beta.-[4-(dimethylamino)phenyl]-17.beta.-hydroxy-17.alpha.-(2-propenyl) estra-4,9-dien-3-one, Van Geerestein et al., Chemical Absts, vol. 106: 129694r.

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