Novel 17.alpha.-aryl-steroids

Details Novel 17.alpha.-aryl-steroids Novel 17.alpha.-aryl-steroids

1978-10-27

1980-12-30

Roberts, Elbert L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2603974, 26039745, 26023955C, C07J 100

Patent

active

042423350

ABSTRACT:
Novel 17.alpha.-aryl-steroids of the formula ##STR1## wherein R.sub.1 is alkyl of 1 to 3 carbon atoms, R.sub.2 is selected from the group consisting of hydrogen, alkyl of 1 to 12 carbon atoms and acyl of an organic carboxylic acid of 1 to 18 carbon atoms, R.sub.3 is aryl of 6 to 12 carbon atoms optionally substituted with at least one substituent selected from the group consisting of --OH, halogen, alkoxy and alkyl of 1 to 4 carbon atoms and --CF.sub.3, the dotted line in the B ring indicating an optional double bond in the 9(10)-position, and A and B are hydrogen and when there is a double bond in the 9(10)-position, A and B form a double bond in the 11(12) position or B is hydrogen and A is an 11.beta.-hydroxy having progestomimetic activity activity without androgenic activity and a process for their preparation and novel intermediates produced therein.

REFERENCES:
patent: 2774777 (1956-12-01), Djerassi et al.
patent: 3069421 (1962-12-01), Nomine et al.
patent: 3086027 (1963-04-01), Perelman et al.
patent: 3176010 (1965-03-01), Cooley et al.
patent: 3178456 (1965-04-01), Wettstein et al.
patent: 3257278 (1966-06-01), Nomine et al.

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