Novel 15-deoxy-16-ethynyl and -16-(1-propynyl)-1-carboxy and 1-c

Details Novel 15-deoxy-16-ethynyl and -16-(1-propynyl)-1-carboxy and 1-c Novel 15-deoxy-16-ethynyl and -16-(1-propynyl)-1-carboxy and 1-c

1978-12-14

1981-02-10

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

562503, C07C17700

Patent

active

042503256

ABSTRACT:
The invention described herein relates to novel 15-deoxy-16-hydroxy-16-ethynyl or 16-(1-propynyl) prostaglandins of E, F, D and A series having on the terminal methylene carbon of the alpha chain a substituent selected from the group consisting of: ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen and C.sub.1 -C.sub.6 alkyl; R.sub.15 is selected from the group consisting of C.sub.1 -C.sub.4 alkyl, di-C.sub.1 -C.sub.4 -alkylamino, phenyl and phenyl substituted with one or more substituents selected from the group consisting of C.sub.1 -C.sub.4 alkyl, OR, SR, F or Cl, wherein R is an alkyl group.

REFERENCES:
patent: 4132738 (1979-01-01), Kluender

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