Novel 10-substituted steroids

Details Novel 10-substituted steroids Novel 10-substituted steroids

1986-01-14

1988-06-28

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514172, 514176, 26039745, 540113, A61K 3156, A61K 3158, C07J 100, C07J 4300

Patent

active

047539321

ABSTRACT:
A novel steroid of the formula ##STR1## wherein X is methylene and R is an optionally substituted carbocyclic aryl or heterocyclic aryl or optionally substituted vinyl or ethynyl or X is a simple bond or --S-- and R is optionally substituted carbocyclic aryl or heterocyclic aryl, R.sub.2 is methyl or ethyl, R.sub.3 is selected from the group consisting of optionally substituted alkyl of 1 to 8 carbon atoms and optionally substituted alkenyl and alkynyl of 2 to 8 carbon atoms, R.sub.4 is selected from the group consisting of hydrogen and acyl, ##STR2## is selected from the group consisting of ##STR3## R.sub.6 is selected from the group consisting of hydrogen and methyl, the wavy line indicates .alpha. or .beta.- and the dotted line in 1(2) indicates the optional presence of a second carbon-carbon bond and novel process and intermediates therefore having anti-glucocorticoid activity.

REFERENCES:
patent: 3132138 (1964-05-01), Nomine et al.
Steroids-Experimental Section; Patrick A. Marcotte & Cecil H. Robinson "Synthesis and Evaluation of 10-Substituted 4-Esterene-3,17-Diones as Inhibitors of Human Placental Microsomol Aromatase" Mar. 1982, pp. 326-333 and p. 1-vol. 39, No. 3.

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