Novel 1-substituted-3-acylpyrrole derivatives, platelet aggregat

Details Novel 1-substituted-3-acylpyrrole derivatives, platelet aggregat Novel 1-substituted-3-acylpyrrole derivatives, platelet aggregat

1978-12-04

1980-11-11

Tovar, Jose

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

2603265J, C07D20700, A61K 3140

Patent

active

042333091

ABSTRACT:
Novel 1-substituted-3-acylpyrrole derivatives of the formula ##STR1## wherein all symbols are as defined in the specification; and platelet aggregation inhibiting agents comprising them as active ingredients. These novel 1-substituted-3-acylpyrrole derivatives are prepared by condensing the corresponding 1-substituted pyrrole derivatives with the corresponding acylating agents in the presence of acid catalysts, and if desired, subjecting the products to oxidation, hydrolysis, amidation or acetal-forming reaction. These 1-substituted-3-acylpyrrole derivatives exhibit unique properties in that they have superior platelet aggregation inhibiting actions with low antiinflammatory activity.

REFERENCES:
patent: 3551571 (1970-12-01), Pachter et al.
patent: 3644631 (1972-02-01), Pachter et al.

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