Novel 1-benzhydryl-4-cinnamylpiperazine derivatives, and pharmac

Details Novel 1-benzhydryl-4-cinnamylpiperazine derivatives, and pharmac Novel 1-benzhydryl-4-cinnamylpiperazine derivatives, and pharmac

1985-12-31

1987-10-27

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544396, A61K 31495, C07D29508

Patent

active

047030488

ABSTRACT:
A 1-benzhydryl-4-cinnamylpiperazine derivative represented by the following formula (I) ##STR1## wherein R.sup.1 represents a hydrogen atom or a methoxy group, and R.sup.2 represents a hydrogen or fluorine atom, or a pharmaceutically acceptable acid addition salt thereof. The compound (I) is prepared by selectively reducing the corresponding 1-benzhydryl-4-cinnamoylpiperazine derivative and optionally converting the product into its acid addition salt. The compound (I) is useful for treatment of cerebrovascular disease in a human.

REFERENCES:
patent: 3773939 (1973-11-01), Janssen
patent: 3957790 (1976-05-01), Suzuki et al.
patent: 4008324 (1977-02-01), Metz et al.
patent: 4528194 (1985-07-01), Masaki
patent: 4663325 (1987-05-01), Ohtaka et al.
Raabe et al, Chem. 93-186413k.
March, Advanced Org. Chem., 2nd edition, pp. 1119-1121.

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