Novel 1,4-dihydropyridine derivatives, process for preparing the

Details Novel 1,4-dihydropyridine derivatives, process for preparing the Novel 1,4-dihydropyridine derivatives, process for preparing the

1986-07-03

1989-04-25

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514336, 514339, 514255, 514318, 546284, 546272, 546194, 546321, 546263, 544365, 544131, A61K 31455, C07D21186

Patent

active

048248371

ABSTRACT:
1,4-Dihydropyridine derivatives of the formula (1): ##STR1## wherein X is a halogen; R.sup.1 is a straight, branched or cyclic alkyl group having 1 to 10 carbon atoms, the group --(CH.sub.2).sub.n -Y [where n is an integer of 0 to 8, provided that n is an integer of 2 to 8 when Y is not bonded to COO-- through carbon; Y is a cyclic alkyl group having 3-6 carbon atoms, an aryl group having 6-10 carbon atoms, a pyrrolidinyl group, an imidazolidinyl group, a thienyl group, a furyl group, an imidazolyl group, a pyridyl group, a pyrimidinyl group, a morpholinyl group, a thiomorpholinyl group or a pyrrolizidinyl group, the group ##STR2## (where D is an aryl or aralkyl group having 6-15 carbon atoms which may be substituted by a halogenated alkyl group), or a 3-piperidinyl group substituted by a phenylalkyl group of 7-10 carbon atoms which may be substituted by one or two halogens], the group --(CH.sub.2).sub.m --O--Z (where m is an integer of 1 to 8; and Z is an alkyl or aryl group), or the group ##STR3## (where l is an integer of 1-7; A is a hydrogen atom, an alkyl group or an aryl group; and R.sup.3 and R.sup.4 which may be the same or different represent an alkyl, aryl or aralkyl group); and R.sup.2 is a lower alkyl group, and pharmaceutically acceptable acid addition salts thereof are effective for treating disorders of the circulatory system and are useful as hypotensives, cerebral circulation improvers and antianginal agents.
Processes for producing the above copounds economically and effectively are also disclosed.

REFERENCES:
patent: 3974275 (1986-08-01), Bosset et al.
patent: 4145432 (1979-03-01), Sato
patent: 4423052 (1983-12-01), Araki et al.

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