Novel 1,1,3,5-substituted biuret compound and a pharmaceutical c

Details Novel 1,1,3,5-substituted biuret compound and a pharmaceutical c Novel 1,1,3,5-substituted biuret compound and a pharmaceutical c

1980-03-27

1981-10-06

Doll, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

424322, A61K 3117, C07C12724

Patent

active

042937132

ABSTRACT:
A novel 1,1,3,5-substituted biuret compound of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are respectively the same or different, and each are alkyl groups having 1 to 4 carbon atoms; R.sup.3 is a cyclohexyl group or a phenyl group which may be unsubstituted or may have at least one substituent selected from the group consisting of chlorine, bromine, fluorine, methyl, trifluoromethyl, dimethylamino, methoxy, methylthio, nitro and acetyl. The novel 1,1,3,5-substituted biuret compounds are useful as an analgesic, anti-inflammatory and/or anti-pyretic agent.

REFERENCES:
patent: 3149338 (1964-09-01), Habicht et al.
patent: 3189431 (1965-06-01), Salzberg
patent: 3253902 (1966-05-01), Munz et al.
patent: 3305549 (1967-02-01), Chubb
patent: 3407193 (1968-10-01), McColl et al.
patent: 3556766 (1971-01-01), Mitchell
Kogon, CA 53:7064e (1958).
Hill, J. Amer. Chem. Soc. 62, 1595 (1940).
Thurman et al., J. Heterocyclic Chemistry, 9, 459-460 (1972).

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